Cannabis and Migraines: A Possible New Treatment Option?<div>
<div>Nancy-Anne Rose
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Cannabis as a medicine has an ancient history with anecdotes dating back to the Vedic period (c.1500 BCE) in India and Nepal. It wasnt until 1839 that William Brooke OShaughnessy introduced the therapeutic potential of cannabis to the western hemisphere, and another 75years after that until Sir William Osler, the father of modern medicine, proposed its use for the treatment of migraines and <a data-ipb="nomediaparse" href="https://www.leafly.com/explore/symptoms-headaches/sort-alpha">headaches</a>. The criminalization of cannabis has since hindered our ability to research its potential; to-date, much of what we understand is largely anecdotal or based on animal or tissue culture experiments.
However, as countries legalize cannabis and as public opinion changes, cannabis research will flourish. What we already know of its ability to treat migraines and headaches is promising.
What is a Migraine and What are the Symptoms?A migraine is a complex condition with a number of symptoms including the following:
- Painful headaches
- Disturbed vision
- Sensitivity to light (photophobia) and sound (phonophobia)
- Nausea and vomiting
- Disorientation
- Problems with coordination
These symptoms can last several hours to several days, and in severe cases reversible paralysis or loss of consciousness can occur.Migraines are triggered by a variety of internal (somatic, physiological) and external (chemical, environmental) variables. People who get migraines are thought to have a genetic predisposition toward having abnormal cells in the brain stem.
What Causes Migraines?
Evidence suggests that migraines are the result of a variety of triggers interacting with a dysfunctional brain stem center involved in pain regulation. These triggers activate the trigeminovascular system (neurons in the trigeminal nerve that supply cerebral blood vessels with nerves), and consequently the dilation of cerebral blood vessels, which in turn activate brain circuits associated with pain and inflammation.
Anandamide and 2-arachidonylglycerol (2-AG) are endogenous <a data-ipb="nomediaparse" href="https://www.leafly.com/news/cannabis-101/cannabinoids-101-what-makes-cannabis-medicine/">cannabinoids</a> naturally found in the nervous system that, together with cannabinoid receptors, form the<a data-ipb="nomediaparse" href="https://www.leafly.com/news/science-tech/is-your-endocannabinoid-system-in-balance/">endocannabinoid system</a> (ECS). When <a data-ipb="nomediaparse" href="https://www.leafly.com/news/cannabis-101/why-does-cannabis-make-you-feel-good/">anandamide</a> and 2-AG interact with cannabinoid receptors, they inhibit blood vessel dilation and modulate the pain mechanisms activated by an individuals triggers (e.g. changes in atmospheric pressure, chocolate, or caffeine).
What are the Current Migraine Treatment Options?
Migraines are treated with a variety of acute (onset of an attack) and prophylactic or preventative medications. The frequency and severity of a migraine, as well as the lifestyle and constitution of an individual, are all factors to consider when choosing the proper medication.
Examples of acute medications for pain relief (analgesics) include acetaminophen, opioids, <a data-ipb="nomediaparse" href="http://www.webmd.com/migraines-headaches/triptans-serotonin-receptor-agonists-for-migraine-headaches">triptans</a>, glucocorticoids (steroid hormones), and <a data-ipb="nomediaparse" href="http://www.mayoclinic.org/drugs-supplements/headache-medicine-ergot-derivative-containing-oral-route-parenteral-route-rectal-route/description/drg-20070161">ergots</a>. In general, preventative medications include a variety of cardiovascular drugs (beta and calcium channel blockers), anti-depressants, anti-convulsants, and non-steroidal anti-inflammatory drugs. Side effects of these medications might include nausea, dizziness, drowsiness, and muscle weakness.
The <a data-ipb="nomediaparse" href="http://www.mayoclinic.org/diseases-conditions/migraine-headache/diagnosis-treatment/treatment/txc-20202474">Mayo Clinic</a> and the <a data-ipb="nomediaparse" href="http://www.mayoclinic.org/diseases-conditions/migraine-headache/diagnosis-treatment/treatment/txc-20202474">Migraine Trust</a> also recommend a variety of complementary therapies including <a data-ipb="nomediaparse" href="https://www.leafly.com/news/health/yoga-cannabis-and-you-6-best-practices-for-pairing-yoga-with-mari/">yoga</a>, tai chi, acupuncture, <a data-ipb="nomediaparse" href="https://www.leafly.com/news/health/cannabis-oil-topical-massage/">massage therapy</a>, biofeedback, hypnotherapy, cognitive behavior therapy, as well as a selection of herbs, vitamins, and minerals. Not surprising, there is no mention of cannabis as a potentially viable approach to the treatment and prevention of migraines.
Can Cannabis be Used as Migraine Treatment and Prevention?<a data-ipb="nomediaparse" href="https://www.leafly.com/news/strains-products/best-cannabis-strains-for-treating-pain/">Pain management</a> is the best known medical benefit of cannabis, most notably of the cannabinoid <a data-ipb="nomediaparse" href="https://www.leafly.com/news/cannabis-101/whats-the-deal-with-these-high-cbd-strains/">CBD</a>, which is thought to have analgesic properties that <a data-ipb="nomediaparse" href="https://www.leafly.com/news/science-tech/could-cannabis-help-treat-painkiller-and-heroin-addiction/">may help reduce a patients dependence prescription opiates</a>as well as manage a host of negative side effects. Patients also use cannabis to help them <a data-ipb="nomediaparse" href="https://www.leafly.com/news/strains-products/the-best-cannabis-strains-for-insomnia/">sleep</a>, <a data-ipb="nomediaparse" href="https://www.leafly.com/news/strains-products/10-cannabis-strains-to-help-stimulate-your-appetite/">stimulate their appetite</a>, and manage mood and <a data-ipb="nomediaparse" href="https://www.leafly.com/news/strains-products/what-are-the-best-cannabis-strains-for-anxiety/">anxiety</a> levels.....
<a data-ipb="nomediaparse" href="https://www.leafly.com/news/health/cannabis-and-migraine-treatment">https://www.leafly.com/news/health/cannabis-and-migraine-treatment</a>