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Scrapping excessive neural connection helps build new connections



Date: January 10, 2017



Source: Osaka University



Summary: Neural activity that retracts excessive early innervation in a certain pathway helps make late neural connections in a different pathway, research has found. This may provide a self-organizing mechanism of neural connections, and additionally, early excessive innervation may serve as a guide for making late neural connections.





Researchers found that neural activity that retracts excessive early innervation in a certain pathway helps make late neural connections in a different pathway. This may provide a self-organizing mechanism of neural connections, and additionally, early excessive innervation may serve as a guide for making late neural connections.



The formation and refinement of neural networks is known to be often an activity-dependent process, but mechanisms and nature of activity are not yet clearly understood.



During neuronal circuit formation, afferent axons often make multiple, exuberant, or aberrant connections, which are later eliminated, sometimes in an activity-dependent manner. Such examples are widely seen throughout the central and peripheral nervous systems....



<a data-ipb="nomediaparse" href="https://www.sciencedaily.com/releases/2017/01/170110092055.htm">https://www.sciencedaily.com/releases/2017/01/170110092055.htm</a>