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Impulsive Behavior Regulated By Cannabinoid 2 - EDDIEKIRK - 05-27-2012
Impulsive Behavior Regulated By Cannabinoid 2 Receptors
Main Category: Psychology / Psychiatry
Also Included In: Schizophrenia; Bipolar
Article Date: 11 Mar 2012 - 0:00 PST
A new study lead by the Neuroscience Institute of Alicante reveals how manipulating the endocannabinoid system can modulate high levels of impulsivity. This is the main problem in psychiatric illnesses such a schizophrenia, bipolar disorder and substance abuse.
Spanish researchers have for the first time proved that the CB2 receptor, which has modulating functions in the nervous system, is involved in regulating impulsive behaviour.
"Such a result proves the relevance that manipulation of the endocannabinoid system can have in modulating high levels of impulsivity present in a wide range of psychiatric and neurological illness," explains SINC Jorge Manzanares Robles, a scientist at the Alicante Neuroscience Institute and director of the study.
Carried out on mice, the study suggests the possibility of undertaking future clinical trials using drugs that selectively act on the CB2 and thus avoid the psychoactive effects deriving from receptor CB1 manipulation, whose role in impulsivity has already been proven.
However, the authors of the study published in the British Journal of Pharmacology remain cautious. Francisco Navarrete, lead author of the study, states that "it is still very early to be able to put forward a reliable therapeutic tool."
The study assessed the actions of two cannabinoid drugs that stimulate and block CB2 in the mouse strain showing high levels of impulsivity. The scientists then analysed whether these drugs were capable of modulating impulsive behaviour and the cerebral modifications associated with this change in behaviour.
The authors concluded that CB2 receptor activity modulation reduced impulsive behaviour in mice, depending on the patterns that governed the administration of each drug. Furthermore, the genetic exp<b></b>ression levels of CB2 tended to return to normal, leaning towards strains that had little impulsivity.
The Endocannabinoid System