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05-07-2012, 02:46 PM
Int J Oncol. 2012 May 14. doi: 10.3892/ijo.2012.1476. [Epub ahead of print]
Cannabinoid-associated cell death mechanisms in tumor models (Review).
Calvaruso G, Pellerito O, Notaro A, Giuliano M.
Source
Department of Experimental Biomedicine and Clinical Neuroscience, Section of Biochemical Sciences, University of Palermo, 90129 Palermo, Italy.
Abstract
In recent years, cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the ability of these compounds to induce different pathways of cell death has been highlighted. Here, we review the most recent results generating interest in the field of death mechanisms induced by cannabinoids in cancer cells. In particular, we analyze the pathways triggered by cannabinoids to induce apoptosis or autophagy and investigate the interplay between the two processes. Overall, the results reported here suggest that the exploration of molecular mechanisms induced by cannabinoids in cancer cells can contribute to the development of safe and effective treatments in cancer therapy.
PMID:22614735 [PubMed - as supplied by publisher] My link
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
<sup>9</sup>-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of <sup>9</sup>-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.
My link
15 Rats with "incurable" brain tumors treated with THC infusions:3 die, 9 live up to twice as long as untreated Rats, 3 had tumors completely eliminated.Effective treatment: 60%
Complete cure: 20%
Cancer Killed by Cannabis - Weed - Pot - Marijuana finds UCLA research and others Full-length Doc
<div><iframe width="459" height="344" src="https://www.youtube.com/embed/iksA-DD3990?feature=oembed" frameborder="0" allowfullscreen="true"></iframe>
Marijuana cures cancer - US government has known since 1974
</div>
Cannabinoid-associated cell death mechanisms in tumor models (Review).
Calvaruso G, Pellerito O, Notaro A, Giuliano M.
Source
Department of Experimental Biomedicine and Clinical Neuroscience, Section of Biochemical Sciences, University of Palermo, 90129 Palermo, Italy.
Abstract
In recent years, cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the ability of these compounds to induce different pathways of cell death has been highlighted. Here, we review the most recent results generating interest in the field of death mechanisms induced by cannabinoids in cancer cells. In particular, we analyze the pathways triggered by cannabinoids to induce apoptosis or autophagy and investigate the interplay between the two processes. Overall, the results reported here suggest that the exploration of molecular mechanisms induced by cannabinoids in cancer cells can contribute to the development of safe and effective treatments in cancer therapy.
PMID:22614735 [PubMed - as supplied by publisher] My link
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
<sup>9</sup>-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of <sup>9</sup>-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.
My link
15 Rats with "incurable" brain tumors treated with THC infusions:3 die, 9 live up to twice as long as untreated Rats, 3 had tumors completely eliminated.Effective treatment: 60%
Complete cure: 20%
Cancer Killed by Cannabis - Weed - Pot - Marijuana finds UCLA research and others Full-length Doc
<div><iframe width="459" height="344" src="https://www.youtube.com/embed/iksA-DD3990?feature=oembed" frameborder="0" allowfullscreen="true"></iframe>
Marijuana cures cancer - US government has known since 1974
</div>