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Alzheimer’s Caused By Loss of Cannabinoids,
#1
Early deficits in Alzheimers may be caused by blockage of the brains cannabinoids, according to new research out of Stanford University.http://med.stanford.edu/news/all-news/20...imers.html







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Clumps of protein in the brain, called beta-amyloid plaques, are the primary marker of Alzheimers disease. For long, scientists knew that these clumps interfered with memory signals in the brain but they werent sure how.

Now a team from Stanford University School of Medicine has traced the effects of beta-amyloid plaque to activity of the brains endogenous cannabinoids, or endocannabinoids. These compounds are produced naturally by the brain and mimic the effects of compounds in cannabis. Among many functions, cannabinoids play a key role in memory and learning.

Endocannabinoids in the brain are very transientLooking at brain slices taken from rats, the researchers observed that clumps of beta-amyloid indirectly impaired memory pathways by interfering with the normal activity of cannabinoids.

This interference with the brains cannabinoids may be the mechanism by which early memory deficits in Alzheimers are formed, says Daniel Madison, PhD, who led the study. Cannabinoids may also present a new opportunity for treating Alzheimers before the disease advances, he adds.

The findings were published June 18 in the journal Neuron.

However, Dr. Madison says it would be inaccurate to assume that smoking cannabis could counteract the effects of beta-amyloid plaque on memory and learning.

Endocannabinoids in the brain are very transient and act only when important inputs come in, explains Dr. Madison. Marijuanas main ingredient, THC, has a much longer-lasting effect, he notes.

Exposure to marijuana over minutes or hours is different: more like enhancing everything indiscriminately, so you lose the filtering effect. Its like listening to five radio stations at once.

On the other hand, a 2013 study by researchers from Neuroscience Research Australia suggests an ingredient in marijuana called CBD could be beneficial. The team, led by Tim Karl, PhD, found that treatment with CBD led to drastic improvements in memory in mice genetically engineered to mimic Alzheimers disease.

Besides the potential to combat Alzheimers symptoms, some studies suggest cannabinoids also hold promise in slowing progression of the disorder.


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#2
Well, my grandparents always thought I was the devil for smoking the herb, now one has Alzheimers. I guess got the last laugh [img]/emoticons/default_LOL.gif[/img]
Reply
#3

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Reply
#4

The Sanford Study Is Really Heavy. I'm Going To Keep Coming Back Until I Connect Everything Up.



Seems Like It's The Only Part Of My Brain That Works<strong>When I Read Just About Anything Medical.</strong>



Chronic cannabidiol treatment improves social and object recognition in double transgenic APP<sub style="font-size:21px;vertical-align:baseline;">swe</sub>/PS1E9 mice



I Like This 2013 Study Too.









Abstract




Rationale



Patients suffering from Alzheimers disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid- (A), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage.






Objectives



The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses A-induced spatial memory deficits in rodents.






Materials and methods



Thus we determined the therapeutic-like effects of chronic CBD treatment (20mg/kg, daily intraperitoneal injections for 3weeks) on the APP<sub style="font-size:12.75px;vertical-align:baseline;">swe</sub>/PS1E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze.






Results



Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours.






Conclusions


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This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.



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On 6/26/2014 at 3:42 PM, EDDIEKIRK said:




The team, led by Tim Karl, PhD, found that treatment with CBD led to drastic improvements in memory in mice genetically engineered to mimic Alzheimers disease.




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Drastic Far-Out !



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<b style="color:rgb(51,51,51);font-size:17px;">Oh Darn, I Passed Over The 'Neuron' Link And Then Went Back A Few </b><font color="#333333"><b>Minutes</b></font><b style="color:rgb(51,51,51);font-size:17px;">Ago. Short But Super Interesting.</b>




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Quote:
On 6/26/2014 at 3:42 PM, EDDIEKIRK said:




Besides the potential to combat Alzheimers symptoms, some studies suggest cannabinoids also hold promise in slowing progression of the disorder.




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Even More Good News... I Wonder Where The Studies Are Now Around The World ? I Must Find A Good Day Or Three



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To Search About For Up To Date Studies... Just Think With All The Access To Cannabis And The Cannabinoids Themselves Specifically...



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New Research Should Really Get The Knowledge Juices Flow'in Eh ?



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Thanks Very Much EK... Most Sincerely, BW


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