Welcome Guest to the new home of OMMP Pay it Forward. Please reset your password reset password! if you haven't already. Make sure to check your spam/junk folder for it. x

Smile Welcome members and clients of OMMP PIF. Due to increased costs, our website has moved to this server,  Thanks go to our Friend and colleague, Wired57, for making this possible.  If you have any questions or concerns, please start a new topic in  Arrow  General, and we'll look right into it.  Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile x

Big Grin Thank you EDDIEKIRK & Cheri! for all your hard work over the years. Big Grin x


Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5
Active component of marijuana and Alzheimer's disease pathology.
#1
Active component of marijuana and Alzheimer's disease pathology.


A molecular link between the active component of marijuana and Alzheimer's disease pathology. AbstractAlzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years. Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients and reduce the health care costs attributable to Alzheimer's disease. Here, we demonstrate that the active component of marijuana, Delta9-tetrahydrocannabinol (THC), competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid beta-peptide (Abeta) aggregation, the key pathological marker of Alzheimer's disease. Computational modeling of the THC-AChE interaction revealed that THC binds in the peripheral anionic site of AChE, the critical region involved in amyloidgenesis. Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Abeta aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.
Links
  • <a class="" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/pdf/">PMC Free PDF</a>
  • <a class="" href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17140265/?tool=pubmed">PMC Free Full Text</a>
  • <a class="" href="http://dx.doi.org/10.1021/mp060066m">Publisher Full Text</a>








[Image: alzheimers-disease.jpg]
Reply




Users browsing this thread: 1 Guest(s)