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07-18-2012, 11:04 PM
<strong>Cannabis compound benefits blood vessels
</strong>
Dr. Dave Allen, a heart surgeon explains marijuana may help avoidance of diseases and conditions.
http://www.youtube.com/watch?v=xHfE9hNJyLI
This computer rendition shows how fatty deposits can narrow blood vessels
![[Image: artery.jpg]](http://www.nature.com/news/2005/050406/images/artery.jpg)
Roxanne Khamsi
A compound derived from the cannabis plant protects blood vessels from dangerous clogging, a study of mice has shown. The discovery could lead to new drugs to ward off heart disease and stroke.
The compound, called delta-9-tetrahydrocannabinol (THC), combats the blood-vessel disease atherosclerosis in mice. This disease occurs when damage to blood vessels, by nicotine from cigarettes, for example, causes an immune response that leads to the formation of fatty deposits in arteries.
These deposits form because the immune cells can linger too long, recruiting others and leading to an inflamed blockage that snares fatty molecules. The disease is the leading cause of heart disease and stroke in the developed world.
Science: Cannabinoids prevented the development of heart failure in animal study
Heart failure is a serious possible consequence of a heart attack or other diseases that damage the heart. It occurs when the heart loses its ability to pump enough blood through the body. Often it develops slowly over years, as the heart gradually loses its pumping ability.
In rats heart failure develops within 12 weeks after a big cardiac infarction. Scientists of the University of Wurzburg in Germany found out that daily application of the synthetic cannabinoid HU-210 after the infarction prevented the drop of blood pressure (left-ventricular systolic pressure) and dysfunction of the arteries (endothelial dysfunction). However, the cannabinoid also increased the filling pressure in the left chamber of the heart (left-ventricular end-diastolic pressure), which may be negative in the long run.
HU-210 activates CB1 receptors as does THC. CB1 receptors are not only found in the brain where they cause the characteristic psychic effects, but also in the heart and many other organs. Dr. Jens Wagner and colleagues treated another group of rats with a selective blocker of the CB1 receptor which reduced the pumping ability of the heart after cardiac infarction.
Researchers concluded that taken together with other results their studies show that endocannabinoids produced by the body itsself excert a protective effect after a heart attack. A commentary by the British Journal of Pharmacology says that "cannabinoids and endocannabinoid systems may therefore present useful targets for therapy following myocardial infarction."
(Sources: Wagner JA, et a. Br J Pharmacol 2003 Apr;138(7):1251-8; Hiley CR, Ford WR. Br J Pharmacol 2003 Apr;138(7):1183-4; press release of the University of Wurzburg of 11 April 2003)
source: http://www.cannabis-...el.php?id=145#2
DIABETES, CARDIOVASCULAR DISEASE | Pot?
Future drugs
THC could be deployed alongside currently used cholesterol-controlling drugs called statins to fight atherosclerosis, Mach suggests. "I don't think this will replace statins. But we may add another compound that will fight against inflammation," he explains.
Because THC might suppress the immune system in a general way, there is a danger that it may harm the body's ability to fight infection. To avoid this, Mach says, it may be necessary to identify similar compounds that specifically target the CB2 protein.
Still, the discovery adds to the range of potential medicinal benefits of cannabis compounds. Besides its well-publicized use for pain relief, the drug is also given to anorexics to stimulate appetite, and cancer patients to combat the nauseating side-effects of chemotherapy
Anatomy & Physiology Online - Cardiac conduction system and its relationship with ECG
<div><iframe width="480" height="270" src="https://www.youtube.com/embed/v3b-YhZmQu8?feature=oembed" frameborder="0" allowfullscreen="true"></iframe>
</strong>
Dr. Dave Allen, a heart surgeon explains marijuana may help avoidance of diseases and conditions.
http://www.youtube.com/watch?v=xHfE9hNJyLI
This computer rendition shows how fatty deposits can narrow blood vessels
Roxanne Khamsi
A compound derived from the cannabis plant protects blood vessels from dangerous clogging, a study of mice has shown. The discovery could lead to new drugs to ward off heart disease and stroke.
The compound, called delta-9-tetrahydrocannabinol (THC), combats the blood-vessel disease atherosclerosis in mice. This disease occurs when damage to blood vessels, by nicotine from cigarettes, for example, causes an immune response that leads to the formation of fatty deposits in arteries.
These deposits form because the immune cells can linger too long, recruiting others and leading to an inflamed blockage that snares fatty molecules. The disease is the leading cause of heart disease and stroke in the developed world.
Science: Cannabinoids prevented the development of heart failure in animal study
Heart failure is a serious possible consequence of a heart attack or other diseases that damage the heart. It occurs when the heart loses its ability to pump enough blood through the body. Often it develops slowly over years, as the heart gradually loses its pumping ability.
In rats heart failure develops within 12 weeks after a big cardiac infarction. Scientists of the University of Wurzburg in Germany found out that daily application of the synthetic cannabinoid HU-210 after the infarction prevented the drop of blood pressure (left-ventricular systolic pressure) and dysfunction of the arteries (endothelial dysfunction). However, the cannabinoid also increased the filling pressure in the left chamber of the heart (left-ventricular end-diastolic pressure), which may be negative in the long run.
HU-210 activates CB1 receptors as does THC. CB1 receptors are not only found in the brain where they cause the characteristic psychic effects, but also in the heart and many other organs. Dr. Jens Wagner and colleagues treated another group of rats with a selective blocker of the CB1 receptor which reduced the pumping ability of the heart after cardiac infarction.
Researchers concluded that taken together with other results their studies show that endocannabinoids produced by the body itsself excert a protective effect after a heart attack. A commentary by the British Journal of Pharmacology says that "cannabinoids and endocannabinoid systems may therefore present useful targets for therapy following myocardial infarction."
(Sources: Wagner JA, et a. Br J Pharmacol 2003 Apr;138(7):1251-8; Hiley CR, Ford WR. Br J Pharmacol 2003 Apr;138(7):1183-4; press release of the University of Wurzburg of 11 April 2003)
source: http://www.cannabis-...el.php?id=145#2
DIABETES, CARDIOVASCULAR DISEASE | Pot?
Future drugs
THC could be deployed alongside currently used cholesterol-controlling drugs called statins to fight atherosclerosis, Mach suggests. "I don't think this will replace statins. But we may add another compound that will fight against inflammation," he explains.
Because THC might suppress the immune system in a general way, there is a danger that it may harm the body's ability to fight infection. To avoid this, Mach says, it may be necessary to identify similar compounds that specifically target the CB2 protein.
Still, the discovery adds to the range of potential medicinal benefits of cannabis compounds. Besides its well-publicized use for pain relief, the drug is also given to anorexics to stimulate appetite, and cancer patients to combat the nauseating side-effects of chemotherapy
Anatomy & Physiology Online - Cardiac conduction system and its relationship with ECG
<div><iframe width="480" height="270" src="https://www.youtube.com/embed/v3b-YhZmQu8?feature=oembed" frameborder="0" allowfullscreen="true"></iframe>
ECG FOR DUMMIES. HEART RATE DETERMINATION TUTORIAL
<div><iframe width="459" height="344" src="https://www.youtube.com/embed/18ePmiL-kIg?feature=oembed" frameborder="0" allowfullscreen="true"></iframe></div>
Heart Anatomy and How it Works
<div><iframe width="459" height="344" src="https://www.youtube.com/embed/lq_WwhGk7XA?feature=oembed" frameborder="0" allowfullscreen="true"></iframe></div>
<strong>Science: THC protects heart cells in the case of lowered oxygen supply
</strong>
Israelian researchers at the Bar-Ilan University in Ramat-Gan demonstrated that THC protects heart cells (cardiomyocytes) against the damage caused by hypoxia (reduced oxygen concentration in the blood) in experimental studies. Pre-treatment of cultures of cardiomyocytes with THC for 24 hours prevented leakage of LDH induced by hypoxia. Leakage of LDH (lactate dehydrogenase) from cells is a sign of cell damage.
This protective effects of THC was mediated by the CB2 receptor. CB2 receptor activation by THC induced the production of nitric oxide (NO). Nitric oxide signals the smooth muscles of blood vessels to relax, thus dilating the artery and increasing blood flow. This underlies the action of nitroglycerin and other drugs used in the treatment of heart disease, since these compounds are converted to nitric oxide in the body.
Researchers noted that THC also "probably pre-trains the cardiomyocytes to hypoxic conditions." They concluded that their research "demonstrates that THC has beneficial effects on cardiac cells and supports the consideration of marijuana for specific medical uses."
(Source: Shmist YA, Goncharov I, Eichler M, Shneyvays V, Isaac A, Vogel Z, Shainberg A. Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production. Mol Cell Biochem 2006;283(1-2):75-83)
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