02-08-2017, 09:46 AM
GW Pharmas cannabis-derived combo med helps brain cancer patients
by <a data-ipb="nomediaparse" href="http://www.fiercebiotech.com/author/ben-adams">Ben Adams</a> | Feb 7, 2017
After failing in an ulcerative colitis test a few yearsback, GW Pharmas cannabis-derived orphan drug treatment has had better luck in a small oncology study for an aggressive type of brain tumor.
In the phase 2 study,the U.K. biopharmas cannabidiol (CBD) and tetrahydrocannabinol (THC) candidate, both of which are active ingredients derived from cannabis, showed positive top-line results from an exploratory placebo-controlled trial in 21 patients with recurrent glioblastoma multiforme, or GBM, a particularly aggressive brain tumor that has a poor prognosis.
The London-based companys trial showed that those with recurrent GBM treated with THC:CBD had an 83% one-year survival rate, compared with 53% for patients in the placebo cohort (although the p-value was close at 0.042).
After an initial safety test, the trial went into a controlled phase where 12 patients were randomized to THC:CBD as add-on therapy, compared with nine patients randomized to placebo (plus standard of care).....
<a data-ipb="nomediaparse" href="http://www.fiercebiotech.com/biotech/gw-pharma-s-cannabis-derived-combo-med-helps-brain-cancer-patients">http://www.fiercebiotech.com/biotech/gw-pharma-s-cannabis-derived-combo-med-helps-brain-cancer-patients</a>
by <a data-ipb="nomediaparse" href="http://www.fiercebiotech.com/author/ben-adams">Ben Adams</a> | Feb 7, 2017
After failing in an ulcerative colitis test a few yearsback, GW Pharmas cannabis-derived orphan drug treatment has had better luck in a small oncology study for an aggressive type of brain tumor.
In the phase 2 study,the U.K. biopharmas cannabidiol (CBD) and tetrahydrocannabinol (THC) candidate, both of which are active ingredients derived from cannabis, showed positive top-line results from an exploratory placebo-controlled trial in 21 patients with recurrent glioblastoma multiforme, or GBM, a particularly aggressive brain tumor that has a poor prognosis.
The London-based companys trial showed that those with recurrent GBM treated with THC:CBD had an 83% one-year survival rate, compared with 53% for patients in the placebo cohort (although the p-value was close at 0.042).
After an initial safety test, the trial went into a controlled phase where 12 patients were randomized to THC:CBD as add-on therapy, compared with nine patients randomized to placebo (plus standard of care).....
<a data-ipb="nomediaparse" href="http://www.fiercebiotech.com/biotech/gw-pharma-s-cannabis-derived-combo-med-helps-brain-cancer-patients">http://www.fiercebiotech.com/biotech/gw-pharma-s-cannabis-derived-combo-med-helps-brain-cancer-patients</a>